I've been seeing so many (unfortunately already locked) posts about moving user profiles to a separate drive and redditors commenting how this is generally a bad idea, but I need to add this piece of knowledge to reddit. There IS indeed a way to move the whole user folder onto another drive without breaking Windows and dependencies. This method does not need external software, it's built-in.
The safest way is doing so during installation/OOBE setup of Windows 10/11, but it CAN work in an existing installation, too. It involves setting up a small XML file and running a sysprep command.
See following link for details! I've been using this technique since many years for Windows 10 and 11 and it works without issues 🙂 the thread covers everything, but I can add my personal experience and remarks if this gets some attention.
https://www.tenforums.com/tutorials/1964-move-users-folder-location-windows-10-a.html