Is it possible to have a certain windows settings option toggle itself when a specified application is launched?

Hello,

I use a mouse in my left hand, and have switched the left and right mouse buttons in windows settings. Unfortunately, games don't pick up on this, and thus the icons they use are incorrect. I'd much rather, for those games, just switch the keybinds in the game settings.

Is it possible for a windows setting to toggle itself when an app is detected?

Cheers!

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