Millicent Quibb school of etiquette for young ladies of mad science

I'm reading through Kate McKinnon's books for the second time (two kids, read it to one, and now the other). It's pretty obvious Kate McKinnon wrote the title character in as herself.

So, question; if you've read the book, who would you cast if it got turned into a movie?

John Cryer as Ashley Cookie Esq jumps to mind.

Leslie Jones as mayor Deweena

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