MushroomClinicalTrials.com – Functional Mushroom Database

2015 Cordyceps militaris The Efficacy and Safety of Cordyceps militaris in Korean Adults Who Have Mild Liver Dysfunction 54 Fruiting Body 1500 mg/day 2015 Cordyceps militaris Cordyceps militaris Enhances Cell-Mediated Immunity in Healthy Korean Men 79 Fruiting Body Ethanol Extract 1500 mg/day 2016 Cordyceps militaris Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation 28 Mix including Myceliated Biomass (oats) 619 mg/day 2019 Cordyceps militaris Effects of Cordyceps militaris supplementation on the immune response and upper respiratory infection in healthy adults- a randomized, double-blind, placebo-controlled study 100 Fruiting Body 300 mg/day 2021 Cordyceps militaris Efficacy and Safety of Cordyceps militaris as an Adjuvant to Duloxetine in the Treatment of Insomnia in Patients With Depression: A 6-Week Double-Blind, Randomized, Placebo-Controlled Trial 59 Fruiting Body 3000 mg/day 2022 Cordyceps militaris The effects of Cordyceps militaris fruiting bodies in micturition and prostate size in benign prostatic hyperplasia patients- A pilot study 62 Fruiting Body 250 mg twice daily 2023 Cordyceps militaris Early Trends to Show the Efficacy of Cordyceps militaris in Mild to Moderate COVID Inflammation 65 Fruiting Body 500 mg three times a day 2024 Cordyceps militaris Improved Oxygen Saturation and Performance of Athletes using Cordyceps militaris 48 Fruiting Body 1000 mg/day 2020 Grifola gargal Medicinal Mushroom, Grifola gargal, Lowers Triglyceride in Animal Models of Obesity and Diabetes and in Adults with Prediabetes 10 Fruiting Body extract 9200 mg/day 2009 Lion’s Mane (Hericium erinaceus) Improving Effects of the Mushroom Yamabushitake (Hericium erinaceus) on Mild Cognitive Impairment 30 Fruiting Body 3000 mg/day 2010 Lion’s Mane (Hericium erinaceus) Reduction of Depression and Anxiety by 4 Weeks Hericium erinaceus Intake 30 Fruiting Body 500 mg/day 2015 Lion’s Mane (Hericium erinaceus) The Effects of Hericium erinaceus (Amyloban® 3399) on Sleep Quality and Subjective Well-being 8 Amyloban® 3399 (with Hericenone A) – 2019 Lion’s Mane (Hericium erinaceus) Improvement of Cognitive Functions by Oral Intake of Hericium erinaceus 31 Fruiting Body 3200 mg/day 2019 Lion’s Mane (Hericium erinaceus) Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity 77 Fruiting Body (20%) and Mycelium (80%) – 2020 Lion’s Mane (Hericium erinaceus) Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium erinaceus Mycelia 41 Mycelium Enriched With Erinacine A A 1050 mg/day (with 15 mg/day of Erinacine A A) 2021 Lion’s Mane (Hericium erinaceus) Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers 13 Mycelium Extract 3000 mg 2022 Lion’s Mane (Hericium erinaceus) Effects of Erinacine A-Enriched Hericium erinaceus on Elderly Hearing-Impaired Patients 80 Mycelium Enriched With Erinacine A A 2000 mg/day (with 10 mg/day of Erinacine A A) 2023 Lion’s Mane (Hericium erinaceus) The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults 41 Fruiting Body and Mycelium 1800 mg/day 2000 Maitake (Grifola frondosa) Effects of Maitake (Grifola frondosa) glucan in HIV-infected patients 35 Fruiting Body and/or MD-Fraction 6000 mg/day or 20 mg +4000 mg/day 2003 Maitake (Grifola frondosa) Effect of Maitake (Grifola frondosa) D-Fraction on the Activation of NK Cells in Cancer Patients 10 D-Fraction 80-300 mg/day 2004 Maitake (Grifola frondosa) Safety of Maitake D-Fraction in Healthy Patients 28 D-Fraction 1 Drop/Kg Body Weight 2009 Maitake (Grifola frondosa) A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects 34 Fruiting Body Extract 2-20 mg/day 2010 Maitake (Grifola frondosa) Maitake Mushroom (Grifola frondosa) Extract Induces Ovulation in Patients with Polycystic Ovary Syndrome 80 Extract 162 mg/day 2015 Maitake (Grifola frondosa) Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study 21 Fruiting Body Extract 6 mg/day 2022 Maitake (Grifola frondosa) Effect of Maitake D-fraction in advanced laryngeal and pharyngeal cancers during concurrent chemoradiotherapy: A randomized clinical trial 141 D-Fraction 3000 mg/day 1999 Ophiocordyceps sinensis Increased Aerobic Capacity in Healthy Elderly Humans Given a Fermentation Product of Cordyceps CS-4 30 CS-4 3000 mg/day 2001 Ophiocordyceps sinensis Supplementation with Cordyceps CS-4 Fermentation Product Promotes Fat Metabolism During Prolonged Exercise 30 CS-4 4500 mg/day 2004 Ophiocordyceps sinensis Randomized Double-blind Placebo-controlled Clinical Trial and Assessment of Fermentation Product of Cordyceps Sinensis (CS-4) in Enhancing Aerobic Capacity and Respiratory Function of The Healthy Elderly Volunteers 37 CS-4 3000 mg/day 2004 Ophiocordyceps sinensis CordyMax Enhances Aerobic Capability, Endurance Performance, and Exercise Metabolism in Healthy, Mid-Age to Elderly Sedentary Humans 131 CS-4 3000 mg/day 2004 Ophiocordyceps sinensis Cordyceps Sinensis (CordyMax CS-4) Supplementation Does Not Improve Endurance Exercise Performance 22 CS-4 3000 mg/day 2005 Ophiocordyceps sinensis Cordyceps sinensis- and Rhodiola rosea-based Supplementation in Male Cyclists and Its Effect on Muscle Tissue Oxygen Saturation 8 CS-4 1,000-2,000 mg/day 2009 Ophiocordyceps sinensis Randomized, Double-Blind, Placebo-Controlled Trial of Herbal Therapy for Children with Asthma 85 Mix including Myceliated Biomass (oats) 0.619 g/day 2010 Ophiocordyceps sinensis Effect of CS-4 (Cordyceps sinensis) on Exercise Performance in Healthy Older Subjects: A Double-Blind, Placebo-Controlled Trial 20 CS-4 333 mg three times a day 2016 Ophiocordyceps sinensis Herbal Medicine Cordyceps sinensis Improves Health-Related Quality of Life in Moderate-to-Severe Asthma Fruiting Body 3600 mg/day 2019 Ophiocordyceps sinensis Immunomodulatory effects of a β-glucan of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial 79 β-glucan extract 1.68 g/day 2021 Ophiocordyceps sinensis Applying Cordyceps sinensis to Boost Endurance Performance in Long-Distance Runners 12 – Not specified 2022 Ophiocordyceps sinensis Effects of cordyceps sinensis supplementation during 12 weeks in amateur marathoners: A randomized, double-blind placebo-controlled trial 30 Fruiting Body 2000 mg/day 2024 Ophiocordyceps sinensis Randomized Double-blind Placebo-controlled Clinical Trial and Assessment of Fermentation Product of Cordyceps Sinensis in Enhancing Aerobic Capacity and Respiratory Function of The Healthy Elderly Volunteers 37 CS-4 – 1995 Reishi (Ganoderma lucidum) Sensitization to Ganoderma lucidum in Patients with Respiratory Allergy in India 172 Fruitng Body and Spore Extract – 2002 Reishi (Ganoderma lucidum) A Phase I/II Study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. Extract (Ganopofy) in Patients with Advanced Cancer 143 Ganopoly (β-glucan extract) 5400 mg/day 2002 Reishi (Ganoderma lucidum) A Phase I/II Study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. (Ling Zhi, Reishi Mushroom) Extract in Patients with Chronic Hepatitis B 90 Ganopoly (β-glucan extract) – 2003 Reishi (Ganoderma lucidum) Effects of Ganopoly1 (A Ganoderma lucidum Polysaccharide Extract) on the Immune Functions in Advanced-Stage Cancer Patients 34 Ganopoly (β-glucan extract) 5400 mg/day 2003 Reishi (Ganoderma lucidum) A Randomized, Placebo-Controlled, Multicenter Study of Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Polysaccharides (Ganopoly®) in Patients with Advanced Lung Cancer 68 Ganopoly (β-glucan extract) 1800 mg/day 2004 Reishi (Ganoderma lucidum) A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.)Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus 71 Ganopoly (β-glucan extract) 5400 mg/day 2004 Reishi (Ganoderma lucidum) A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Coronary Heart Disease 168 Ganopoly (β-glucan extract) – 2005 Reishi (Ganoderma lucidum) Phase I Study of a Methanol Extract of Ganoderma lucidum, Edible and Medicinal Mushroom, in Men with Mild Symptoms of Bladder Outlet Obstruction 50 Methanol Extract 0.6, 6, or 60 mg/day 2005 Reishi (Ganoderma lucidum) Immune Responses to Water-Soluble Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.) P. Karst. Polysaccharides in Patients with Advanced Colorectal Cancer 47 Ganopoly (β-glucan extract) 5400 mg/day 2005 Reishi (Ganoderma lucidum) Effects of Water-Soluble Ganoderma lucidum Polysaccharides on the Immune Functions of Patients with Advanced Lung Cancer 36 Ganopoly (β-glucan extract) 5400 mg/day 2005 Reishi (Ganoderma lucidum) A Randomized, Double-Blind and Placebo-Controlled Study of a Ganoderma lucidum Polysaccharide Extract in Neurasthenia 132 Ganopoly (β-glucan extract) 5400 mg/day 2005 Reishi (Ganoderma lucidum) A Prospective, Randomized, Double-Blind, Placebo-Controlled Study of the Platelet and Global Hemostatic Effects of Ganoderma Lucidum (Ling-Zhi) in Healthy Volunteers 40 Ganopoly (β-glucan extract) 1500 mg/day 2007 Reishi (Ganoderma lucidum) Safety and Tolerability of Ganoderma lucidum in Healthy Subjects: A Double-Blind Randomized Placebo-Controlled Trial 16 Fruiting Body and Spore Extract 4000 mg/day (1.89% terpenoids and 15.8% polysaccharides) 2007 Reishi (Ganoderma lucidum) Safety and Efficacy of Ganoderma lucidum (Lingzhi) and San Miao San Supplementation in Patients With Rheumatoid Arthritis: A Double-Blind, Randomized, Placebo-Controlled Pilot Trial 65 Unspecified Extract 4000 mg/day 2007 Reishi (Ganoderma lucidum) Potential Benefits of Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) to Breast Cancer Patients 1 Triterpene-enriched polysaccharide extract – 2007 Reishi (Ganoderma lucidum) Effect of an Extract of Ganoderma lucidum in Men with Lower Urinary Tract Symptoms: A Double-Blind, Placebo-Controlled Randomized and Dose-Ranging Study 88 Unspecified Extract 0.6, 6, or 60 mg/day 2008 Reishi (Ganoderma lucidum) Randomized Clinical Trial of an Ethanol Extract of Ganoderma Lucidum in Men with Lower Urinary Tract Symptoms 88 Fruiting Body Alcohol Extract 6 mg/day 2011 Reishi (Ganoderma lucidum) Study of Potential Cardioprotective Effects of Ganoderma Lucidum (Lingzhi): Results of a Controlled Human Intervention Trial 26 Unspecified Extract 1440 mg/day 2011 Reishi (Ganoderma lucidum) Spore Powder of Ganoderma Lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial 48 Spore Powder 3000 mg/day 2013 Reishi (Ganoderma lucidum) Preliminary Study of the Applications of Ganoderma Lucidum in Chronic Fatigue Syndrome 50 Unspecified Extract 2000 mg/day 2014 Reishi (Ganoderma lucidum) Control of Oral Human Papillomavirus (HPV) by Medicinal Mushrooms, Trametes versicolor and Ganoderma lucidum: A Preliminary Clinical Trial 61 Fruiting Body 200 mg/day 2015 Reishi (Ganoderma lucidum) Useful Treatment of Severe Atopic Dermatitis with Ganoderma Lucidum: A Multiple-Case Study 4 Fruiting Body 2700 mg/day 2015 Reishi (Ganoderma lucidum) A Randomized Double Blinded Study of Ganoderma lucidum (Lingzhi) in Salvage Setting of Recurrent Gynecologic Cancer 60 Fruiting Body + Spores Water Extract 6000 mg/day 2016 Reishi (Ganoderma lucidum) A Double-Blind, Randomized, Placebo-Controlled Trial of Ganoderma lucidum for the Treatment of Cardiovascular Risk Factors of Metabolic Syndrome 84 10:1 Fruiting Body Extract (75%) + Spores (25%) 3000 mg/day 2017 Reishi (Ganoderma lucidum) Triterpenoids and Polysaccharide Peptides-Enriched Ganoderma Lucidum: A Randomized, Double-Blind Placebo-Controlled Crossover Study of Its Antioxidation and Hepatoprotective Efficacy in Healthy Volunteers 42 Extract (7% ganoderic acids and 6% β-Glucan) 225 mg/day 2017 Reishi (Ganoderma lucidum) The Role of Ganoderma Lucidum Uptake on Some Hematological and Immunological Response in Patients with Coronavirus (COVID-19) 150 Unspecified Extract – 2017 Reishi (Ganoderma lucidum) Cost-Utility Analysis of a Six-Weeks Ganoderma Lucidum-Based Treatment for Women with Fibromyalgia: A Randomized Double-Blind, Active Placebo-Controlled Trial 26 Micromilled Ganoderma lucidum 6000 mg/day 2018 Reishi (Ganoderma lucidum) Spore Powder of Ganoderma Lucidum for the Treatment of Alzheimer Disease: A Pilot Study 42 Spore Powder – 2018 Reishi (Ganoderma lucidum) Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with β-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellín, Colombia 124 β-glucans extract – 2018 Reishi (Ganoderma lucidum) Immunostimulatory and Anti-inflammatory Effect of Ganoderma Lucidum on Breast Cancer Patients 40 Ganoderma Lucidum capsules 2000 mg/day 2019 Reishi (Ganoderma lucidum) β-1,3/1,6-d-glucan Of Indonesian Ganoderma Lucidum β-glucan Reduces Systolic Blood Pressure & Inflammation In Hypertensive Patients 50 β-glucan extract 540 mg/day 2020 Reishi (Ganoderma lucidum) Transarterial Chemoembolization in Hepatocellular Carcinoma: A Clinical Efficacy Study of Ganoderma Lucidum Extract Polysaccharide Peptide β-Glucan 63 β-glucan extract – 2020 Reishi (Ganoderma lucidum) Ganoderma lucidum Polysaccharide Peptide Reduce Inflammation and Oxidative Stress in Patient with Atrial Fibrillation 38 PPGL (β-glucan extract) 750 mg/day 2020 Reishi (Ganoderma lucidum) Ganoderma Lucidum Effects on Mood and Health-Related Quality of Life in Women with Fibromyalgia 64 Fruiting Body 6000 mg/day 2020 Reishi (Ganoderma lucidum) Effects of a Combination of Elderberry and Reishi Extracts on the Duration and Severity of Respiratory Tract Infections in Elderly Subjects: A Randomized Controlled Trial 60 Fruiting Body (standardized to 35% polysaccharides) 500 mg/day 2020 Reishi (Ganoderma lucidum) Dynamic biomarkers indicate the immunological benefits provided by Ganoderma spore powder in post-operative breast and lung cancer patients 120 Spore Powder 4000 mg/day 2021 Reishi (Ganoderma lucidum) A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Reishi Mushroom (Ganoderma lucidum), Stinging Nettle (Urtica dioica), and Epimedium (Epimedium sagittatum) 29 Fruiting Body + Extract – 2022 Reishi (Ganoderma lucidum) Evaluation of Immune Modulation by β-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomized Controlled Trial 135 β-glucan extract 200 mg/day 2022 Reishi (Ganoderma lucidum) The Efficacy of Ganoderma lucidum in Overweight Individuals: A Randomized Placebo-controlled trial 72 Fruiting Body + Extract 780 mg/day 2022 Reishi (Ganoderma lucidum) The Potential Activity of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), to Alleviate Liver Injury in Adults with Acute Mushroom Poisoning: A Retrospective Study 61 – – 2023 Reishi (Ganoderma lucidum) Combination Treatment in Ulcerative Colitis Using 5-Aminosalysilic Acid (5-ASA) and Polysaccharide Peptide of Indonesian Ganoderma lucidum β-glucan 124 PPGL (β-glucan extract) 540 mg/day 2023 Reishi (Ganoderma lucidum) Medicinal Mushroom, Ganoderma Lucidum, Improves Painful Symptoms in Patients with Restless Legs Syndrome 20 Unspecified Extract 920 mg/day 2024 Reishi (Ganoderma lucidum) Survival Benefits of Ganoderma Lucidum in Early-stage Triple-negative Breast Cancer: A Real World Study 142 Spore Powder – 1992 Shiitake (Lentinula edodes) Immunological Analysis and Clinical Effects of Intraabdominal and Intrapleural Injection of Lentinan for Malignant Ascites and Pleural Effusion 16 Lentinan 4 mg/week intracavitary injection 1992 Shiitake (Lentinula edodes) Enhanced Production of Interleukin 1 and Tumor Necrosis Factor by Peripheral Monocytes After Lentinan Administration in Patients with Gastric Carcinoma 10 Lentinan 2 mg intravenously 1992 Shiitake (Lentinula edodes) Enhanced Induction of Lymphokine-Activated Killer Activity After Lentinan Administration in Patients with Gastric Carcinoma 15 Lentinan 2 mg intravenously 1998 Shiitake (Lentinula edodes) Eosinophilia and Gastrointestinal Symptoms After Ingestion of Shiitake Mushrooms 10 Fruiting Body 4000 mg/day 1998 Shiitake (Lentinula edodes) A Placebo-Controlled Trial of the Immune Modulator, Lentinan, in HIV-Positive Patients: A Phase I/II Trial 98 Lentinan 10, 5, 2, or 1 mg/day 1999 Shiitake (Lentinula edodes) The preoperative administration of lentinan ameliorated the impairment of natural killer activity after cardiopulmonary bypass 25 Lentinan 2mg/day intravenously 2002 Shiitake (Lentinula edodes) Effects of a Mushroom β-glucan on the Treatment of Prostate Cancer 62 β-glucan extract ≈1000mg/10kg BW 2006 Shiitake (Lentinula edodes) Efficacy of Lentinan Combined with Chemotherapy in Advanced Non-Small Cell Lung Cancer 81 Lentinan – 2008 Shiitake (Lentinula edodes) Clinical Application of a Combination Therapy of Lentinan, Multi-Electrode RFA and TACE in HCC 78 Lentinan 500 mg/day 2010 Shiitake (Lentinula edodes) Dietary Administration of Mushroom β-glucans in Patients with Early Stage Prostate Cancers Managed Expectantly: A Phase II Study 74 AHCC (β-glucan extract) 4500 mg/day 2010 Shiitake (Lentinula edodes) Efficacy of Orally Administered Superfine Dispersed Lentinan (β-1,3-Glucan) for the Treatment of Advanced Colorectal Cancer 80 SDL (Superfine dispersed lentinan) 15 mg/day 2011 Shiitake (Lentinula edodes) Supplementation with a Soluble Beta-Glucan Exported from Shiitake Medicinal Mushroom, Lentinus edodes (Berk.) Singer Mycelium: a Crossover, Placebo-Controlled Study in Healthy Elderly 42 Lentinan 2.5 mg/day 2011 Shiitake (Lentinula edodes) Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy 68 Lentinan – 2011 Shiitake (Lentinula edodes) Efficacy of Orally Administered Lentinula edodes Mycelia Extract for Advanced Gastrointestinal Cancer Patients Undergoing Cancer Chemotherapy- a Pilot Study 8 β-glucan extract – 2011 Shiitake (Lentinula edodes) Efficacy and Safety of Orally Administered Lentinula edodes Mycelia Extract for Patients Undergoing Cancer Chemotherapy: A Pilot Study 7 β-glucan extract 1800 mg/day 2011 Shiitake (Lentinula edodes) Combination therapy with lentinan improves outcomes in patients with esophageal carcinoma 50 Lentinan 1 mg 2011 Shiitake (Lentinula edodes) Clinical observation of thermotherapy combined with thoracic injection of lentinan in treatment of cancerous hydrothorax of patients with lung cancer 60 Lentinan (β-glucan extract) – 2011 Shiitake (Lentinula edodes) Testing a Low Molecular Mass Fraction of a Mushroom (Lentinus edodes) Extract Formulated as an Oral Rinse in a Cohort of Volunteers 90 Fruiting Body Extract – 2012 Shiitake (Lentinula edodes) The Anticaries Effect of a Food Extract (Shiitake) in a Short-Term Clinical Study 30 Fruiting Body Extract – 2012 Shiitake (Lentinula edodes) The Effect of Lentinan Combination Therapy for Unresectable Advanced Gastric Cancer 39 Lentinan 2 mg 2013 Shiitake (Lentinula edodes) Efficacy of Oral Administration of Lentinula edodes Mycelia Extract for Breast Cancer Patients Undergoing Postoperative Hormone Therapy 20 β-glucan extract 1800 mg 2014 Shiitake (Lentinula edodes) Dietary Supplementation with Rice Bran Fermented with Lentinus edodes Increases Interferon-\u03b3 Activity without Causing Adverse Effects: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study 80 Mycelliated Substrate 3000 mg/day 2015 Shiitake (Lentinula edodes) Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults 52 Fruiting Body 5 or 10 g/day 2016 Shiitake (Lentinula edodes) Randomized phase III study of S-1 alone versus S-1 plus lentinan for unresectable or recurrent gastric cancer 309 Lentinan 2 mg/body 2016 Shiitake (Lentinula edodes) Polysaccharide from Lentinus edodes for Integrative Cancer Treatment: Immunomodulatory Effects on Lymphocyte Population 7 AHCC (β-glucan extract) 300 mg/day 2016 Shiitake (Lentinula edodes) Improvement of QOL and Immunological Function With Lentinula Edodes Mycelia in Patients Undergoing Cancer Immunotherapy: An Open Pilot Study 10 Randomized phase III study of S-1 alone versus S-1 plus lentinan for unresectable or recurrent gastric cancer 1800 mg/d 2016 Shiitake (Lentinula edodes) Chemo-Immunotherapy Using Lentinan for the Treatment of Gastric Cancer with Liver Metastases 12 Lentinan 2 mg 2016 Shiitake (Lentinula edodes) A phase II study of a combination treatment of alternate-day S-1 and lentinan as first-line chemotherapy for unresectable or recurrent gastric cancer 37 Lentinan 2 mg/body 2017 Shiitake (Lentinula edodes) Lentinula edodes mycelia extract plus adjuvant chemotherapy for breast cancer patients: Results of a randomized study on host quality of life and immune function improvement 47 β-glucan extract 1,800 mg/day 2018 Shiitake (Lentinula edodes) Immunomodulatory Effect of Lentinan on Aberrant T Subsets and Cytokines Profile in Non-small Cell Lung Cancer Patients 73 Lentinan 4 mg/day 2018 Shiitake (Lentinula edodes) Clinical effects of lentinan combined with budesonide inhalation in treating acute exacerbation of chronic obstructive pulmonary disease under mechanical ventilation 72 Lentinan 0.5 g 2018 Shiitake (Lentinula edodes) Lentinan combined with cisplatin and paclitaxel in the treatment of patients with ovarian cancer with ascites 212 Lentinan – 2019 Shiitake (Lentinula edodes) An open label trial of a standardized extract of cultured Lentinula edodes mycelia (ECLM) in children with refractory epilepsy 18 β-glucan extract 0.6 g/day 2020 Shiitake (Lentinula edodes) S-1 Plus Leucovorin and Oxaliplatin in Combination with Lentinan as First-line Therapy in Patients with Metastatic Gastric Cancer 12 Lentinan – 2020 Shiitake (Lentinula edodes) A Quality-of-Life Study in Healthy Adults Supplemented with Lentinex\u00ae Beta-Glucan of Shiitake Culinary\u2212Medicinal Mushroom, Lentinus edodes (Agaricomycetes) 63 Lentinan 1-2 mg 2020 Shiitake (Lentinula edodes) Modulation of T Regulatory and Dendritic Cell Phenotypes Following Ingestion of Bifidobacterium longum, AHCC\u00ae and Azithromycin in Healthy Individuals 40 AHCC (β-glucan extract) – 2021 Shiitake (Lentinula edodes) Preventing Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy With Active Hexose-correlated Compound Derived From Lentinula edodes Mycelia 29 AHCC (β-glucan extract) 1000 mg 2021 Shiitake (Lentinula edodes) Modulation of human intestinal microbiota in a clinical trial by consumption of a \u03b2\u2010d\u2010glucan\u2010enriched extract obtained from Lentinula edodes 52 Fruiting Body Extract 3.5 g/day 2021 Shiitake (Lentinula edodes) Lentinan Combined with (125)I Brachytherapy for Recurrent Ovarian Cancer 160 Lentinan – 2021 Shiitake (Lentinula edodes) Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial 68 Fruiting Body – 2023 Shiitake (Lentinula edodes) Safety and efficacy of lentinan nasal drops in patients infected with the variant of COVID-19: a randomized, placebo-controlled trial 70 Lentinan 100 mg/day 2023 Shiitake (Lentinula edodes) Efficacy of Lentinula edodes Mycelia Extract on Chemotherapy-Related Tasted Disorders in Pancreatic Cancer Patients 98 AHCC (β-glucan extract) – 2017 Turkey Tail (Trametes versicolor) Coriolus versicolor (Yunzhi) Use as Therapy in Advanced Hepatocellular Carcinoma Patients with Poor Liver Function or Who Are Unfit for Standard Therapy 15 PSP(β-glucan extract) 2.4 g g/day 2022 Turkey Tail (Trametes versicolor) Efficacy of a Coriolus versicolor-Based Vaginal Gel in Human Papillomavirus-Positive Women Older Than 40 Years: A Sub-Analysis of PALOMA Study 41 Topical Gel (Papilocare®) Papilocare® vaginal gel once daily for 21 days, followed by 7 days rest, for 1 or 3 months. Then, alternate-day therapy for 5 or 3 months. 1986 Turkey Tail (Trametes versicolor) Clinical results of a randomized controlled trial on the effect of adjuvant immunochemotherapy using Esquinon and Krestin in patients with curatively resected gastric cancer 279 PSK (β-glucan extract) 2000 mg/m2/day 1988 Turkey Tail (Trametes versicolor) Clinical effect of postoperative adjuvant immunochemotherapy with the FT-207 suppository and PSK in colorectal cancer patients 124 PSK (β-glucan extract) 3000 mg/day 1988 Turkey Tail (Trametes versicolor) Postoperative Adjuvant Immunochemotherapy with Mitomycin Futraful and PSK for Gastric Cancer 579 PSK (β-glucan extract) 3000 mg/day 1989 Turkey Tail (Trametes versicolor) Adjuvant PSK Immunotherapy in Patients with Carcinoma of the Nasopharynx 38 PSK (β-glucan extract) 1000 mg/day 1989 Turkey Tail (Trametes versicolor) An effect of adjuvant immunochemotherapy using krestin and 5-FU on gastric cancer patients with radical surgery (first report)–a randomized controlled trial by the cooperative study group 262 PSK (β-glucan extract) 3000 mg/day 1990 Turkey Tail (Trametes versicolor) Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer 111 PSK (β-glucan extract) 3000 mg/day followed 2/g day 1992 Turkey Tail (Trametes versicolor) Randomized Adjuvant Trial to Evaluate the Addition of Tamoxifen and PSK to Chemotherapy in Patients with Primary Breast Cancer 967 PSK (β-glucan extract) – 1992 Turkey Tail (Trametes versicolor) Randomized, Controlled Study on Adjuvant Immunochemotherapy with PSK in Curatively Resected Colorectal Cancer 448 PSK (β-glucan extract) – 1993 Turkey Tail (Trametes versicolor) Effect of krestin PSK as Adjuvant Treatment on the Prognosis after Radical Radiotherapy in Patients with Non-Small Cell Lung Cancer 185 PSK (β-glucan extract) – 1994 Turkey Tail (Trametes versicolor) Efficacy of Immunochemotherapy as Adjuvant Treatment after Curative Resection of Gastric Cancer 262 PSK (β-glucan extract) – 1994 Turkey Tail (Trametes versicolor) Oxidative Stress Relief for Cancer-Bearing Hosts by the Protein-Bound Polysaccharide of Coriolus versicolor QUEL with SOD Mimicking Activity 18 PSK (β-glucan extract) 3000 mg/day 1995 Turkey Tail (Trametes versicolor) Immunochemotherapies versus Chemotherapy as Adjuvant Treatment after Curative Resection of Operable Breast Cancer 227 PSK (β-glucan extract) – 1995 Turkey Tail (Trametes versicolor) Immunotherapy for Esophageal Cancer: A Randomized Trial in Combination with Radiotherapy and Radiochemotherapy 174 PSK (β-glucan extract) – 1996 Turkey Tail (Trametes versicolor) Postoperative Adjuvant Randomised Trial Comparing Chemoendocrine Therapy, Chemotherapy and Immunotherapy for Patients with Stage II Breast Cancer: 5-year Results 916 PSK (β-glucan extract) 3000 mg/day 1997 Turkey Tail (Trametes versicolor) HLA Antigen as Predictive Index for the Outcome of Breast Cancer Patients with Adjuvant Immunochemotherapy with PSK 134 PSK (β-glucan extract) 3000 mg/day 2003 Turkey Tail (Trametes versicolor) Adjuvant Therapy With Protein-Bound Polysaccharide K and Tegafur Uracil in Patients With Stage II or III Colorectal Cancer: Randomized, Controlled Trial 201 PSK (β-glucan extract) 3000 mg/day 2003 Turkey Tail (Trametes versicolor) Coriolus versicolor Polysaccharide Peptide Slows Progression of Advanced Non-Small Cell Lung Cancer 68 PSP(β-glucan extract) 3060 mg/day 2004 Turkey Tail (Trametes versicolor) Adjuvant Immunochemotherapy with Oral Tegafur/Uracil Plus PSK in Patients with Stage II or III Colorectal Cancer: A Randomized Controlled Study 205 PSK (β-glucan extract) 3000 mg/day 2004 Turkey Tail (Trametes versicolor) Effect of Adjuvant Immunochemotherapy with PSK for Colon Cancer Patients Showing Oncogenic \u03b2-Catenin Activation in Primary Tumor 202 PSK (β-glucan extract) 3000 mg/day 2004 Turkey Tail (Trametes versicolor) Long-term Effect of 5-Fluorouracil Enhanced by Intermittent Administration of Polysaccharide K after Curative Resection of Colon Cancer: A Randomized Controlled Trial for 7-Year Follow-up 446 PSK (β-glucan extract) 3000 mg/day 2004 Turkey Tail (Trametes versicolor) Immunomodulatory Effects of Yun Zhi and Danshen Capsules in Healthy Subjects—a Randomized, Double-Blind, Placebo-Controlled, Crossover Study 100 PSP(β-glucan extract) 50 mg/kg body weight 2005 Turkey Tail (Trametes versicolor) Immunomodulatory Activities of Yunzhi and Danshen in Post-treatment Breast Cancer Patients 82 PSP(β-glucan extract) 50 mg/kg body weight 2006 Turkey Tail (Trametes versicolor) Beneficial Effects of Protein-Bound Polysaccharide K Plus Tegafur/Uracil in Patients with Stage II or III Colorectal Cancer: Analysis of Immunological Parameters 205 PSK (β-glucan extract) 3000 mg/day 2006 Turkey Tail (Trametes versicolor) Clinical Studies of Immunomodulatory Activities of Yunzhi-Danshen in Patients with Nasopharyngeal Carcinoma 27 PSK (β-glucan extract) 3600 mg/day 2007 Turkey Tail (Trametes versicolor) Adjuvant Immunochemotherapy with Protein-Bound Polysaccharide K for Colon Cancer in Relation to Oncogenic β-Catenin Activation 202 PSK (β-glucan extract) – 2007 Turkey Tail (Trametes versicolor) In vivo effect of I’m-Yunity on hepatic cytochrome P450 3A4 12 PSP(β-glucan extract) – 2012 Turkey Tail (Trametes versicolor) Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer 11 Myceliated Substrate (not specified; from fungi perfecti) 3, 6, or 9 g/day 2014 Turkey Tail (Trametes versicolor) Effects of polysaccharopeptide from Trametes Versicolor and amoxicillin on the gut microbiome of healthy volunteers 24 PSP(β-glucan extract) – 2017 Turkey Tail (Trametes versicolor) Phase III Trial Comparing UFT + to UFT + LV in Stage IIB, III Colorectal Cancer 357 PSK (β-glucan extract) 3000 mg/day 2017 Turkey Tail (Trametes versicolor) Randomized Phase III Trial Comparing Surgery Alone to UFT+ PS for Stage II Rectal Cancer (JFMC38 Trial) 111 PSK (β-glucan extract) 3000 mg/day 2024 Turkey Tail (Trametes versicolor) Adjuvant Chemotherapy With UFT/LV Versus UFT/LV Plus PSK in Stage II/III Colorectal Cancer 186 PSK (β-glucan extract) 3000 mg/day 2011 (specific compound) The Bioavailability of Ergothioneine from Mushrooms and Effects on Antioxidant Capacity and Inflammation 10 Ergothioneine 8g or 16g mushroom powder 2012 (specific compound) Improvement of Joint ROM and Reduction of Chronic Pain with Ergothioneine-Containing Supplement 12 Ergothioneine Unspecified 2014 (specific compound) Clinical and Biochemical Correlates of Serum L-Ergothioneine 439 Ergothioneine Observational study (no supplementation)​ 2017 (specific compound) Administration of Pure Ergothioneine to Healthy Subjects 47 Ergothioneine 5 mg and 25 mg daily​ 2022 (specific compound) Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in the Elderly 470 Ergothioneine Observational study (no supplementation)​ 2024 (specific compound) Investigating Ergothioneine to Delay Cognitive Decline in Mild Cognitively Impaired Subjects 19 Ergothioneine 25 mg 3 times per week​ 2023 Tremella fuciformis Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial 64 Fruiting Body Extract 56 mg/day for 8 weeks 2012 Tremella mesenterica Yellow brain culinary-medicinal mushroom, Tremella mesenterica Ritz.:Fr. (higher Basidiomycetes), is subjectively but not objectively effective for eradication of Helicobacter pylori: a prospective controlled trial 52 Fruiting Body Extract 4 g/day for 10 days 2018 Tremella fuciformis Efficacy and Safety of Tremella fuciformis in Individuals with Subjective Cognitive Impairment: A Randomized Controlled TrialEdit | Quick Edit | Trash | View 75 Fruiting Body Extract 600 or 1200 mg/day 2019 Agaricus blazei (Royal Sun Agaric) Agaricus blazei-Based Mushroom Extract Supplementation to Birch Allergic Blood Donors 60 AndoSan™ (Agaricus blazei-based) 60 ml/day 2011 Agaricus blazei (Royal Sun Agaric) Agaricus blazei Murrill and Inflammatory Mediators in Elderly Women 57 Fruiting Body Extract 900 mg/day 2008 Agaricus blazei (Royal Sun Agaric) The Mushroom Agaricus blazei Murill Extract Normalizes Liver Function in Patients with Chronic Hepatitis B 4 Fruiting Body Extract 1500 mg/day 2007 Agaricus blazei (Royal Sun Agaric) The Mushroom Agaricus blazei Murill in Combination with Metformin and Gliclazide Improves Insulin Resistance in Type 2 Diabetes 60 Fruiting Body Extract 1500 mg/day 2015 Agaricus blazei (Royal Sun Agaric) Immunomodulatory Effects of the Agaricus blazei Murill-Based Mushroom Extract AndoSan™ in Patients with Multiple Myeloma 40 AndoSan™ (Agaricus blazei-based) 60 ml/day 2016 Agaricus blazei (Royal Sun Agaric) Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract AndoSan™ on Symptoms, Fatigue, and Quality of Life in Patients with Ulcerative Colitis 50 AndoSan™ (Agaricus blazei-based) 60 ml/day 2016 Agaricus blazei (Royal Sun Agaric) Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract AndoSan™ on Symptoms, Fatigue, and Quality of Life in Patients with Crohn’s Disease 50 AndoSan™ (Agaricus blazei-based) 60 ml/day 2017 Agaricus blazei (Royal Sun Agaric) Royal Sun Culinary-Medicinal Mushroom Agaricus brasiliensis Supplement in Training Capacity Improvement 5 Fruiting Body Not specified 2016 Agaricus blazei (Royal Sun Agaric) Cytokine Levels After Consumption of a Medicinal Agaricus blazei Murill-Based Mushroom Extract AndoSan™ in Patients with Crohn’s Disease and Ulcerative Colitis 50 AndoSan™ (Agaricus blazei-based) 60 ml/day 2006 Agaricus blazei (Royal Sun Agaric) Effects on Gene Expression and Viral Load of a Medicinal Extract from Agaricus blazei in Patients with Chronic Hepatitis C Infection 5 Fruiting Body Extract 60 ml/day 2004 Agaricus blazei (Royal Sun Agaric) Natural Killer Cell Activity and Quality of Life Improved by Agaricus blazei Murill Kyowa in Gynecological Cancer Patients Undergoing Chemotherapy 100 Fruiting Body Extract Not specified 2016 Antrodia (Taiwanofungus) Efficacy and safety of oral Antrodia cinnamomea mycelium in mildly hypertensive adults: A randomized controlled pilot clinical study 41 Pure Mycelium 1260 mg/day 2022 Antrodia (Taiwanofungus) A Botanical Drug Extracted From Antrodia cinnamomea – A First-in-human Phase I Study in Healthy Volunteers 18 LEAC-102 – Purified Compound 500-3000 mg/day 2016 Antrodia (Taiwanofungus) A preliminary randomised controlled study of short-term Antrodia cinnamomea treatment combined with chemotherapy for patients with advanced cancer 37 Pure Mycelium 80 ml/day 2017 Antrodia (Taiwanofungus) Complementary Efficacy of Antrodia cinnamomea Mycelia on Patients with Chronic Hepatitis C Virus Infection: A Randomized Controlled Pilot Clinical Study 60 Pure Mycelium 4680 mg/day 2020 Antrodia (Taiwanofungus) A Pilot Study to Assess Food Safety and Potential Cholesterol-Lowering Efficacy of Antrodia cinnamomea Solid-State Cultivated Mycelium in Healthy Adults 32 Solid-State Mycelium Not specified 2020 Antrodia (Taiwanofungus) Hepatoprotective Effect of Antrodia cinnamomea Mycelium in Patients with Nonalcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial 28 Pure Mycelium 1260 mg/day 2023 Antrodia (Taiwanofungus) Hepatoprotective effect of Antrodia Cinnamomea mycelia extract in subhealth Japanese adults- a randomized, double-blind, placebo-controlled clinical study Not specified Mycelium Extract Not specified 2019 Antrodia (Taiwanofungus) Phase II multicenter study of antroquinonol in patients with stage IV non-small cell lung cancer who have failed at least two lines of anti-cancer therapy Not specified Antroquinonol – Purified Compound Not specified 2017 Antrodia (Taiwanofungus) Effects of Antrodia Camphorata Mycelia Extract Containing Antroquinonol on Lowering Low-Density Lipoprotein Cholesterol: A Randomized Double-Blind Study 26 Extract containing Antroquinonol 25 mg w/ 0.68 mg of Antroquinono 2015 Antrodia (Taiwanofungus) A Phase I Multicenter Study of Antroquinonol in Patients with Metastatic Non-Small-Cell Lung Cancer Who Have Received at Least Two Prior Systemic Treatment Regimens, Including One Platinum-Based Chemotherapy Regimen 13 Antroquinonol – Purified Compound 50-600 mg 2024 Reishi (Ganoderma lucidum) Ganoderma lucidum Dry Extract Supplementation Modulates T Lymphocyte Function in Older WomenGanoderma lucidum Dry Extract Supplementation Modulates T Lymphocyte Function in Older Women 60 Fruiting Body Extract 2022 A Randomized Controlled Trial on Pleurotus eryngii Mushrooms with Antioxidant Compounds and Vitamin D2 in Managing Metabolic Disorders 100 Whole mushroom In Snack 6000 mg/day 2014 Oyster Mushrooms (Pleurotus sp.) Anti-allergic Effect of Pleuran (β-glucan from Pleurotus ostreatus) in Children with Recurrent Respiratory Tract Infections 175 Pleuran (β-glucan from P. ostreatus) 10 mg/kg/day (in syrup with vitamin C), 6 months 2011 Oyster Mushrooms (Pleurotus sp.) Antihyperlipidemic effects of Pleurotus ostreatus (oyster mushrooms) in HIV-infected individuals taking antiretroviral therapy 25 Freeze-dried P. ostreatus powder 15,000 mg/day (15 g/day) 2025 Oyster Mushrooms (Pleurotus sp.) Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma 230 Pleuran (β-glucan from P. ostreatus) 200 mg/day (100 mg pleuran + 100 mg vitamin C), 24 weeks 2015 Oyster Mushrooms (Pleurotus sp.) Beta-(1,3/1,6)-D-glucan Helps to Decrease Opportunistic Infections in Crohn’s Disease Patients Treated with Biological Therapy 53 Pleuran (β-glucan from P. ostreatus) 100 mg/day (pleuran only), 12 months 2022 Oyster Mushrooms (Pleurotus sp.) Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study 1030 Pleuran (β-glucan from P. ostreatus) 10 mg/day (β-glucan) + 10 mg vitamin C, 3 months 2024 Oyster Mushrooms (Pleurotus sp.) Consuming Mushrooms When Adopting a Healthy Mediterranean-Style Dietary Pattern Does Not Influence Short-Term Changes of Most Cardiometabolic Disease Risk Factors in Healthy Middle-Aged and Older Adults 60 Whole mushrooms 84000 mg/day 2022 Oyster Mushrooms (Pleurotus sp.) Dietary Supplementation with Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), Reduces Visceral Fat and Hyperlipidemia in Inhabitants of a Rural Community in Mexico 30 Whole mushrooms 1 kg/week 2010 Oyster Mushrooms (Pleurotus sp.) Effect of Pleuran (β-glucan from Pleurotus ostreatus) supplementation on cellular immune response after intensive exercise in elite athletes 20 Pleuran (β-glucan from P. ostreatus) 100 mg/day β-glucan + 100 mg vitamin C, 2 months 2024 Oyster Mushrooms (Pleurotus sp.) Effect of Pleurotus ostreatus Water Extract Consumption on Blood Parameters and Cytokine Values in Healthy Volunteers x Water extract of P. ostreatus 100 mL/day (38.1 mg β-glucan/100 mL), 29 days 2024 Oyster Mushrooms (Pleurotus sp.) Effects of an ergothioneine-rich Pleurotus sp. on skin moisturizing functions and facial conditions: a randomized, double-blind, placebo-controlled trial 80 Pleurotus tablets rich in ergothioneine 25 mg/day ergothioneine (from 5.8 g dried mushroom), 12 weeks 2013 Oyster Mushrooms (Pleurotus sp.) Effects of Pleurotus ostreatus on Blood Pressure and Glycemic Status of Hypertensive Diabetic Male Volunteers 27 Pleurotus powder in capsules 3000 mg/day 2020 Oyster Mushrooms (Pleurotus sp.) Efficacy of Pleuran (β-Glucan from Pleurotus ostreatus) in the Management of Herpes Simplex Virus Type 1 Infection 90 Pleuran (β-glucan from P. ostreatus) Acute phase: 300 mg/day; Preventive phase: 100 mg/day, both with vitamin C & zinc 2016 Oyster Mushrooms (Pleurotus sp.) Enhancement of the Th1-phenotype immune system by the intake of Oyster mushroom (Tamogitake) extract in a double-blind, placebo-controlled study 41 Water extract of Pleurotus cornucopiae (Tamogitake) 80 mL/day (24 mg β-glucan), 8 weeks 2014 Oyster Mushrooms (Pleurotus sp.) Hypoglycaemic Activity of Culinary Pleurotus ostreatus and P. cystidiosus Mushrooms in Healthy Volunteers and Type 2 Diabetic Patients on Diet Control and the Possible Mechanisms of Action 44 (22 per group healthy volunteers), 28 (14 per group diabetics) Freeze-dried mushroom powder (P. ostreatus or P. cystidiosus) 50 mg/kg body weight 2021 Oyster Mushrooms (Pleurotus sp.) Immunomodulation with β-glucan from Pleurotus ostreatus in patients with endocrine-dependent breast cancer 195 (49 in treatment group) Pleuran (β-glucan from P. ostreatus) 700 mg/day or 100–700 mg/day cyclical over 15 months 2013 Oyster Mushrooms (Pleurotus sp.) Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections 175 Pleuran + Vitamin C 10 mg pleuran and 10 mg vitamin C per mL; 1 mL per 5 kg body weight 2011 Oyster Mushrooms (Pleurotus sp.) Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes 50 Pleuran + Vitamin C 200 mg/day (100 mg β-glucan + 100 mg vitamin C), 3 months 2022 Oyster Mushrooms (Pleurotus sp.) Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity 19 Cooked Whole Mushroom Not specified 2017 Oyster Mushrooms (Pleurotus sp.) Preventive effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections – open-label prospective study 191 Pleuran + Vitamin C 10 mg pleuran + 10 mg vitamin C per mL, dosed at 1 mL per 5 kg body weight) 2023 Oyster Mushrooms (Pleurotus sp.) The Short-Term Variation of Human Gut Mycobiome in Response to Dietary Intervention of Different Macronutrient Distributions 28 Whole Mushroom Cooked Not specified (dietary exposure only) 2015 Oyster Mushrooms (Pleurotus sp.) β-Glucan-based cream (containing pleuran isolated from Pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis 105 Topical Pleuran Cream Topical: 0.25% cream, 2–3x/day 2011 Oyster Mushrooms (Pleurotus sp.) Lipid Lowering Effects of Oyster Mushroom (Pleurotus ostreatus) in HumansLipid Lowering Effects of Oyster Mushroom (Pleurotus ostreatus) in Humans 20 Freeze-dried Pleurotus ostreatus in soup 30 g/day freeze-dried (equiv. 300 g fresh) 2017 Reishi (Ganoderma lucidum) The Role of Ganoderma Lucidum Uptake on Some Hematological and Immunological Response in Patients with Coronavirus (COVID-19) 71 Ganoderma Beta-Glucan 750 mg/day 2003 Ophiocordyceps sinensis CordyMax reduces serum oxidized LDL-cholesterol and increases HDL-cholesterol in humans with reduced HDL-cholesterolCordyMax reduces serum oxidized LDL-cholesterol and increases HDL-cholesterol in humans with reduced HDL-cholesterol 85 CS-4 3000 mg/day 1985 Lion’s Mane (Hericium erinaceus) A Double-Blind Study on Effectiveness of Hericium erinaceus Pers Therapy on Chronic Atrophic Gastritis: A Preliminary ReportA Double-Blind Study on Effectiveness of Hericium erinaceus Pers Therapy on Chronic Atrophic Gastritis: A Preliminary Report 50 Hericium erinaceus extract Not specified (3-month treatment) 2023 Lion’s Mane (Hericium erinaceus) Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion’s Mane Extracts on Cognitive Performance 40 Lion’s Mane fruiting body extract (Nordic) 1000 mg single dose 2025 Hericium erinaceus Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study 18 10:1″ Fruiting Body Extract 3000 mg